My dr put me on Topamax with the Phen to help curb binge and nighttime eating. I haven't filled it yet because the phen alone right now curbs that. I am getting a B12/Lipotropic shot each week. I have to meet with the doctor again next week because she wants me to go back on Metformin, but I don't want to, so I'm trying to lose as much as I can before then I wouldn't take Alli just because too many people I know have gone through way too many panties with that stuff I'll stick with the Phen for a while, I am scared to take anything else with it, especially weight loss aids because I have high BP... don't need anything else to contribute to that. talk to your Dr, that is really the only person that knows your history and can help you out Good luck!