I take Phen and I had high cholesterol. VERY high. It has actually gone down to normal in the month I have been on it. I have Mitral Valve prolapse too and take it with no issue.
The only side effects I have had are: Minor headaches in beginning, serious case of dry mouth (which you just drink a TON of water for); constipation and being hot/sweating more.
Other than that, I really love it. I can absolutely tell it works!