phentermine affects your heart

How Phentermine Affects Your Heart

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On our phentermine forum, there is a lot of speculation about how phentermine affects your heart, with posts on this topic ranging from worrying accounts about heart problems that have been directly attributed to taking phentermine, to posts which confidently state that phentermine cannot cause such problems. But what’s the truth? Here we explain more about how phentermine affects your heart and what side effects to look out for in order to ensure good heart health while you’re taking phentermine.

Phentermine Contraindications

Firstly, it is important to clarify that phentermine is not suitable for everyone, and that is particularly the case if you have ever suffered from heart problems. For this reason, you must always divulge your complete medical history to your doctor before you are prescribed phentermine. You should not take phentermine if you have a history of heart disease, or severe or uncontrolled blood pressure. Phentermine is also not suitable for those with other conditions such as an overactive thyroid, glaucoma, a history of pulmonary hypertension, or if you have a history of drug or alcohol abuse. If you have an appointment with a doctor in order to be prescribed phentermine, you should especially make sure to tell him or her if you have any of the following: high blood pressure, diabetes, kidney disease, a thyroid disorder, or an aspirin allergy. It is vital to disclose all of your medical history and that of any close relatives if the doctor requests this too; even if you think it is unrelated, it is important for your safety that your doctor is properly informed of any potential there may be for a negative reaction to the medication, especially when it comes to heart health.

Before being prescribed phentermine, as well as asking about your medical history, your doctor should test your blood pressure and other indicators of general health, and will only prescribe phentermine if he or she feels that it will not cause additional risks to your health. One phentermine forum user here states that although phentermine may increase the risks of a heart problem, obesity is a guaranteed risk to the heart and your health in general. However, that is not to say that putting your health further at risk by taking something known to be dangerous in your particular case is an option; your doctor should always choose the best course of action for you based on your particular case. Individual differences affect how our bodies metabolize drugs such as phentermine, which is why we all experience different results and different side effects. So, phentermine can only be considered as an option for you if it is deemed safe for you; phentermine has been both effective and safe for many people during its 60 year history and is still the most widely prescribed weight loss medication in the US, but that does not mean that it’s safe for everyone.

If your doctor doesn’t think phentermine is the right option for you, whether it’s due to heart problems or for any other reason, the phentermine alternative Phen Caps can provide you with a solution. Phen Caps do not contain phentermine and have no side effects nor any potential to cause heart problems. In fact, Phen Caps contain crateagus spp. extract, a hawthorn berry extract which is well known for its benefits to cardiovascular health. Hawthorn berries are used in traditional medicine for the treatment of chronic heart failure, high blood pressure, irregular heartbeat, and digestive problems. They have also been shown to improve performance and endurance during exercise, decreasing effects such as shortness of breath and fatigue. In addition to these health-promoting effects, Phen Caps also help you to lose weight in the same way as phentermine by suppressing appetite and boosting energy with its combination of innovative ingredients.

How Phentermine Affects Your Heart

Phentermine works by acting on the central nervous system to stimulate the release of neurotransmitters in our brain, including dopamine, epinephrine (adrenalin) and norepinephrine (noradrenalin). This causes phentermine to reduce appetite and minimize cravings, as well as increasing energy levels and boosting metabolism. However, alongside a faster metabolism, the additional adrenalin is likely to increase your heart rate as a result. This is because there is a direct correlation between heart rate and metabolism – much like when you are working out or scared, your heart rate increases to enable more blood and oxygen to circulate your body and feed your muscles. An accelerated heart rate is therefore considered normal while you are taking phentermine. Furthermore, stress caused by dieting, and phentermine side effects such as anxiety and jitteriness, can also increase your heart rate so it’s important to take steps to de-stress your life and keep healthy by getting all the essential nutrients you need while you’re taking phentermine.

However, if your heartbeat becomes irregular or skips a beat, or if you experience any kind of pain or discomfort, especially in your arms or chest, then you should contact your doctor immediately. Due to the way it is metabolized by the body, phentermine does put additional pressure on the heart and it is for this reason that it cannot be taken by anyone with existing heart problems, and why caution should be exercised if you have conditions such as high blood pressure, as phentermine can exacerbate such issues. There is no good correlation between pulse rate and blood pressure, but an increase in blood pressure is also a possible side effect of phentermine. If you are worried about an increase in blood pressure then you should consult your doctor who will be able to tell you if the increase you are experiencing is within the normal range or not.

phentermine affects your heart

Even if you think that you have a healthy heart or have never experienced problems or symptoms before, it is essential to be vigilant as heart problems can present themselves at any time. Furthermore, several phentermine forum members have explained that they had never had heart problems prior to taking phentermine but experienced serious heart problems either after or while taking phentermine, such as sinus arrhythmia and seizures, and were informed by their doctors that these issues were as a direct result of taking phentermine. While it’s not certain whether these phentermine users actually had undetected heart problems or not, it is certain that the way in which phentermine affects your heart means that symptoms of heart problems can arise seemingly from nowhere while you are taking it.

It is unfortunate that some forum members have been incorrectly reassured by doctors that phentermine does not cause heart problems, as this forum member found when she was later given the opposite information by another doctor. If you are ever concerned or unsure about something that you have been told by your doctor, it is advisable to get a second opinion where possible, as your health should always be yours and your doctor’s priority. Some forum members also dismiss the idea that phentermine causes heart problems and state that it is only the now banned phentermine combination, Fen Phen, which caused these types of issues. While it is true that Fen-Phen and fenfluramine – the other ingredient of the combination – are both banned, whereas phentermine continues to be prescribed, that is not to say that phentermine alone cannot cause heart problems. The number and severity of the health problems caused by Fen-Phen were far beyond reported cases of heart problems linked to phentermine alone, but these cases do still exist, which is why you should be vigilant about side effects and symptoms while taking phentermine.

Phentermine Side Effects Indicative Of Heart Problems

Phentermine comes with a variety of side effects; some of the most common include dry mouth, anxiety, insomnia, constipation, nausea and mood swings. But, in addition to these uncomfortable but otherwise less serious side effects, phentermine can also cause side effects which are cause for concern, such as fainting, swelling across the body, and psychosis. These types of more serious side effects are listed in full here, and should be reported to your doctor immediately. Of the list, those which could indicate heart issues include shortness of breath, a racing heartbeat, irregular heartbeat, dizziness and fainting, arm pain, chest pains, and an elevated blood pressure reading.

Several members on the phentermine forum have posted that they have experienced stabbing chest pains, including this thread, where the forum member states that she is afraid to tell her doctor about the chest pains in case he stops her phentermine prescription. We would like to stress that this is a very reckless and dangerous way to view your health; side effects like these cannot be ignored and should certainly not be hidden from your doctor. Even if you think you have no heart problems, due to the way phentermine affects your heart, you may begin to experience side effects from a previously undetected issue. The phentermine forum includes posts from phentermine users who have developed serious heart problems and have been told by their doctors that it is as a direct result of taking phentermine, such as this member, who speaks about the possibility of being fitted with a pacemaker due to having developed an irregular heartbeat. She states that all the doctors she has seen agree that this is due to phentermine, since she had no heart problems prior to starting phentermine. While it’s possible that she may have had an undetected heart problem, this also highlights the fact that in some cases, phentermine is prescribed to patients whose previously undetected problem with no symptoms then converts into a very serious heart problem due to the ways in which phentermine affects your heart. She lists her symptoms as palpitations, dizziness, short sharp chest pains, shortness of breath and arm pain, and urges that anyone who is experiencing similar symptoms goes to their doctor straight away.

The bottom line is, although phentermine is generally a safe medication when prescribed to obese individuals with otherwise good overall health, any serious side effects should be reported immediately to your doctor. This is particularly the case if you experience any pains or symptoms that may indicate that your heart is at risk due to the way in which phentermine affects your heart. If you are obese, losing weight is the best thing you can do for your health and for your heart, but risking your health and possibly your life to lose weight is not worth it.


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48 Responses

  1. I am slightly concerned because occasionally I suffer from anxiety for which I take Diazipam(Valium). I do not want this to affect the taking of phentermine on my system or make my anxiety worse. I have no heart problems or high blood pressure (my issues are emotional with regard to anxiety). Once I get to my optimum weight I will stop taking phentermine, I only need to really lose 18lbs. I am aware to not take them in conjunction with caffeine because this will just make me feel jittery. I will listen to my body and if i think it\’s having an adverse affect then i will stop taking it or maybe just not take it every day.

    It is worthy to not that I have taken what was said to be Chinese herbal diet tablets, they stated there would be no side affects however the affects on my body were quite severe, I did lose weight but constantly felt Jittery. I\’m convinced they contained speed because it gave me terrible skin and all i wanted to do was drink coffee and smoke cigarettes.

    I would just like to make sure that the use of my Valium won\’t conflict with the taking of Phentermine? Also I do like to have a bottle of wine at the weekend and what is the significance of taking alcohol while on Phentermine?


    • Hi Liz, thanks for your questions. We actually just published an article about taking medications with phentermine, so here’s the link for that: The article mainly stresses the importance of asking your doctor before combining medications with phentermine, so this would be something that you’d have to ask him or her about. Did you ask about this at the time you were given your phentermine prescription? And, if you have two different doctors prescribing these two medications, it would also be advisable to ask your other doctor so you have two opinions to go by.

      In response to your question about phentermine and alcohol, we have also published an article about this: Alcohol slows down weight loss by putting pressure on the liver and also weakens the effects of phentermine by increasing the acidity of your urinary pH, so it is advisable to try and drink less alcohol in order to maximize your potential to lose weight with phentermine.

      Hope that helps!

      • Sally

        There is no correlation between pulse and blood pressure? Huh?

        Ever heard of this?:

        CO = HR x SV

        HR goes up so does CO. And only two things affect blood pressure: CO and resistance.

        So, there is a huge correlation between pulse and blood pressure.

  2. When is the best time of day to take phentermine?
    Is Phendimetrazin 35 mg tabs the same as above?
    thank you

    • Hi Linda,
      Phendimetrazine is similar to phentermine – it works in the same way and has similar side effects. However, phendimetrazine can be taken more than once a day while phentermine is only taken once per day. Phentermine is best taken first thing in the morning, before eating. However, we don’t know if the same applied to phendimetrazine so you would have to ask your doctor about this.

  3. Hi, I am a marathoner, and I have BINGE disorder. My doctor prescribed Phentermine 37mg to be taken once a day, but every time I go for a fast run, my heart rate goes sky high! Of course I cannot sustain my usual speeds with a HR of 190, when at the same speed but without Phentermine my HR is 175.
    I want to lose some more weight, but I am not willing to sacrifice my marathon times because of an unusually high HR. (My AVG resting HR is 55, now on Phentermine is 70)

    Should I stop taking it? Any other alternative appetite suppressors that does not cause an increase in my HR?

    Thank you!

    • Hi John,
      You should speak to your doctor before stopping to take phentermine. He or she may be able to recommend an alternative, or if not, we recommend the phentermine alternative Phen Caps which suppress appetite and boost energy with no increase in heart rate or any other side effects. You can find out more about how they work here:

  4. I have taken Phentermine for five weeks with good results. I have been checking my blood pressure regularly–no concerns. The second week I was taking it, I had an exam for life insurance purposes. Just received a call from the insurance company stating that the level of proBPN in my blood was 214. Anything over 150 kicks me into a higher risk category as there is a link with heart failure if proBPN is elevated. Is this something that may have been caused by Phentermine? Past bloodwork did not test for proBPN so I have no way of knowing what the level was before beginning to take Phentermine. I have, of course, called my family doctor who prescribed Phentermine and am waiting for his response.

    • Hi Lynne,
      It’s certainly possible that phentermine has increased your proBPN level, as it can affect the heart in other ways, not just in relation to blood pressure. Hopefully your doctor can explain more to you and help you in some way to reduce your levels.

  5. I have just started taking phentermine, as I can’t seem to keep a steady weight, been gaining a lot after my heart attack in September 2015, I am on Brilinta, losartan, metoprolol, pravastatin, and now got prescribed phentermine and amlodipine, I noticed that my pulse is elevated, laying between 115-120 but have a good blood pressure 108/75, I am worried now when I read this article, that it’s too much for my heart after the heart attack and stent put in

    • Hi Gertie,
      If your doctor has prescribed phentermine then he or she must think that it´s safe for you. That said, you will need to be extra vigilant when it comes to side effects and how you feel. Be sure to keep your doctor informed of any changes or effects which concern you in any way. Good luck!

  6. Hi I started taking this drug before , I had no problem I had missed my appt after my 3 month follow up ,I just went back I started taking it again it give me bad heart burn I took 3 different heartburn meds still is not reliefs it should I stop taking Phentermine I had no hearts problem.

    • Hi Pat,
      Heartburn isn’t typically a side effect of phentermine – are you sure it’s not something more serious like chest pain, as that is a serious side effect of phentermine. If you’re worried or with a lot of discomfort then we would advise you to speak to your doctor. If it is heartburn it is more likely to be related to the food you’re eating. It’s best to eat slowly and take your time to really chew your food. You should also avoid foods that aggravate heartburn, such as alcohol, spicy food, chocolate, citrus fruits, coffee, soda, peppermint and tomatoes.
      Hope that helps!

  7. I was taking Phentermine for 4 years off and on… I am a professional truck driver. Last year I had an episode of supraventricular tachycardia. I was taking HCG shots and drinking protein shakes with 30 or more grams of protein. I have went from a weight of 230 pounds to 270 in the last year. I am at my heaviest weight ever. I am now taking Toprol 25 which is a beta blocker, not for high blood pressure. I take a multivitamin and after my last episode I was told I had low magnesium so I take a multivitamin for that too. I was given metformin but it does not work with the weight loss like Phentermine did. I wanted to know if I can take something else to help with my weight loss again that does not speed up my heart rate. I have never had any heart issues. I was always healthy, I’ve never had high blood pressure, diabetes or any other health issues.

    • Hi NaKeisha,
      Unfortunately most diet pills affect the heart and are not suitable for people who have experienced any kind of related problem. We recommend a non-prescription weight loss supplement called Phen Caps which have no side effects and no health risks. They also contain the ingredient hawthorn berry extract, which is used in traditional medicine for the treatment of chronic heart failure, high blood pressure, irregular heartbeat, and digestive problems, so they can actually help with heart issues. Here is a link for you to find out more about Phen Caps:

    • The best result I ever had with weight loss is the HMR DIET! My Cardiologist hughlt recommended it. I started last Tuesday..and lost 7 pounds. You eat all the time. Phase 1…no grocery shopping..except fruits a veggies.. You pay for the food and its tasty. Google it. I honestly can’t do the diet I have the same thing you do.

      • There is No magic pill! Adipex..causes might have good results…but I will not take this crap! starts with nutrition. This crap caused me skipped heart beats..panic problems..higher blood pressure..glad to blood pressure is 106/60.. Heart rate 75! I lost 43 pounds Naturally! Staying away from trigger foods! You folks taking this just will ruin your health.

  8. I have been taking adipex for several weeks and I have taken it in the past and I get coldness going down my right arm. My arms seem to be mottled and discolored on the upper arm. Not sure if this a side effect of adipex.

    • Hi Dawn,
      While what you are describing doesn’t sounds like a side effect of phentermine, if you are concerned about it then you should speak to your doctor, if only for some peace of mind that it is nothing to worry about.

  9. I have taken phentermine before and lost 70 pounds. I stopped taking for a year, had my gallbladder removed, holidays came and basically gained 40 lbs back. So now I am back on it. I have always had normal / low blood pressure, but always higher end of normal heart rate. I have been back on phentermine for about a week now. My blood pressure is in its normal ranges. My heart rate is higher though. I know that it can increase heart rate, but I guess my question is, with a normal high heart rate ranging 90-110, is it that big of a deal for me? I would think not if it’s only increased by 20 to 30… all lab work is normal and no health issues, besides weight, I’m a healthy 35 year old…

  10. Are these side effects seen immediately or over long term use? My Dr. Seems to think I only need to use it for a month.

    • Hi Kassandra,
      It depends on the person – some healthy people with no history of heart problems have developed heart issues within short periods of time on phentermine, while other people take phentermine for much longer and never experience these types of side effects. It’s always best to trust your doctor’s advice if he or she is erring on the side of caution.

  11. Hello all,

    I just thought that I’d weigh in, so to speak, on the effects of phentermine. My doctor prescribed it for me as I had high cholesterol and was probably 40 lbs overweight and was concerned that I would develop heart problems as a result. Well after taking phentermine for several months and losing weight (approx 35 lbs) I did, in fact, develop heart problems. I had a heart attack! This was in 2008! I am grateful that there was very minimal damage and that I have successfully changed my lifestyle and exercise regularly. However, I firmly believe that this cardiac event was directly attributed to the use of this drug as I did not have a family history of heart disease on either side.

    Please consider other options IMHO.

  12. You have listed in your side effects that a ‘racing heart rate’ is a serious concern, so my question is, if tachycardia is a normal effect then what do you concider a ‘racing heart rate’? Thanks

    • Hi Melissa,
      It very much depends on the person and what they’re doing to know whether a ‘racing heart rate’ is a concern or not. For example, if someone is sat doing nothing and their heart is racing then this could be cause for concern, whereas if someone is walking and feels their heart beating faster then normal this is not necessarily a concern. Similarly, it depends what the person’s heart rate was before taking phentermine. However, if your heart is skipping or there is chest pain or a ‘fluttering’ feeling in your chest then these are all very serious signs that you should speak to your doctor immediately.

  13. I tried to take phentermine with my history of Afib. I cut 37.5 mg in half and I still had pain in chest and skipped beats. I stopped it and I would like people out there to know this medication is a very serious drug. My pharmacist said the psychosis is a sure side effect. I’m 52 and would like to lose about 30 pounds. I wanted a quick weight loss, I’m doing it the traditional way now. Eating healthy and exercise.

  14. Hi,
    So I have been taking this diet pill for about a month or so. I didn’t take it for two days because I work different work schedules and didn’t want to take it in the afternoon. When I took it again after the two days have passed, I have been experiencing random heart pains, constipation, bad abdominal pain, and nausea. I did not have these symptoms before. I went to the hospital and explained my symptoms and they sent me out the door claiming I have a flu. I did inform them that I was taking phentermine. Could these issues randomly start up from this diet pill ?

    • Hi Jessica,
      These side effects are all reported in relation to phentermine. However, the heart pains suggest signs of a more serious reaction so we would advise you to stop taking phentermine and speak to your doctor to see if it is wise for you to continue or if you should stop altogether.

  15. This is my third day on 15 mg phentermine. I take it at 6 in the morning and after an hour eat my breakfast. I also take 500 mg Metformin to control my sugar levels as I’m borderline diabetic. I take Metformin at 10 pm after dinner. The doctor is totally ok with me taking metformin and Phen together. Two hours after taking phen I am feeling very edgy. No shortness of breath but feel like my heart is racing. Very freaked out. Any input really appreciate it.

  16. I have been taking phentermine for about 10/11 days & have been experiencing sharp pains in my upper left chest. They normally last for a few seconds then go away then come back about a minute etc. this goes on for about 20min then it stops. Well, it started again last night around 8pm & is still going on. I put in a call to my PCP but haven\’t received a call back as of yet. I also have not taken the phentermine today. Is this something that could be stemming from its use? Any input would be great

    • Hi Jill! Yes, you should definitely get in-touch with your PCP/see a doctor right away about this. Hope you’re feeling better today!

    • Hi Jill.

      What did your doctor say? I was on this 3 years ago and only had dry mouth but this is day 16 of my new batch to help me with a little weight lots and you\’ve just described how I felt on Saturday (which is why I did not take yesterday). Did you carry on? Was your doctor okay? Please let me know.

  17. I take half of a 37.5 phentermine 3/4 days a week. I seem to be in a better in a mood on the days I take it. Anyone else have this positive side effect? No palpatations, no high blood pressure.

  18. I took phentermine off and on for 2 years. I was 32 with absolutely NO medical issues other than slightly over weight. Now I have bp issues with the right side of my heart swollen. If I work out I pass out and I also have tingling and pain in arms and chest. These symptoms are brought on by any form of exercise if I\’m cleaning the house or simply at work. My cardiologist and PCP both agree that all of these symptoms were brought on bc of phentermine. I am now having to wear a heart monitor daily. I JUST WANT MY LIFE BACK.

    • Hi how are you doing now? What were your symptoms at first?

  19. Hi, I started phentermine and topormax 2 days ago the first day took it at 10am road stationery for 27 min did well beside couldn\’t get to sleep til after 12 took them this morning at 630am work 12 hours and when I laid down felt slight palpitations and still not sleepy. This is my 3rd round 1st round when I was in my twentys worked fine no problems. 2nd time in my thirtys heart palpitations was to much. So I thought I\’ll try it again cause I\’m 240 the most I\’ve been. Hopefully the palpitations will go away. I did take a 800 motrin cause I was hurting from working so long and hard today, is taking motrin ok while on phentermine?

    • Hi Mandy, thanks for your comment! We always recommend that you double-check with your doctor or pharmacist about specific drug interactions with phentermine.

  20. I started taking 15 mg of Phentermine about three weeks ago. Other than a little headache the first day or two everything seemed fine. This past Sunday while taking my dog for a walk in the park I started getting irregular heart beats. A few hours later in the ER an EKG said I was in afib. I spent the night with an IV drip of Cardizem my heart rhythm converted back to normal about 5 hrs later. They suspect it was caused by the Phentermine and will be advising my Metabolic doctor.

  21. Well I took 1/2of Adipex in the morning..and the other 1/2 in the afternoon. Some chest pain is noted..but my bp is was elevated to normal.. and my heart rate is 75. I usually take half..due to a whole 37.5 is way to much..and then anxiety comes odd.

  22. I am going the healthy route and kicking this drug to the curb. From thw ground or a tree..and no pills for me!

  23. Hi I have a question, I had been taking phentermine for a few months and have recently stopped because I was getting ready to start a weight loss program with my husband, this weight loss program is monitored by a team of doctors and before I start it, I had to do an EKG and my heart rate came back as abnormal and skipping beats. The doctor was surprised and when I told him I had taken phentermine his eyes opened wide and he became concerned. He has sent a referral to the cardiologist but I am so very nervous about this. I know that while on phentermine your hearth speeds up could this be why my heart was skipping beats and does it go back to normal after a while?

  24. I had no issues the day I took it…it was the day after I heart rate..and anxiety. I am not taking it today.

    • Hi Lynne!

      We suggest you consult with your prescribing doctor about this. It’s a known, possible side-effect of phentermine. Your doctor might suggest a different dosage or stopping the treatment altogether, but it’s better to check with him or her first.



  25. hi i started phen last week this is day 7 im just abit worried this morning my
    heart was racing for just a min or so but i think that was because i was very hungry and did not have breakfast as yet but as soon as i eat it went back to normal i want to know is that a problem or is it normal.

    • Hi Amy! It’s common for phentermine to make your heart race due to its stimulant properties. However, if you’ve still feeling anxious and/or this happens again, we’d suggest calling your doctor. He or she may knows your history best and may have some advice about how to decrease this uncomfortable symptom.

  26. Hello…8wks ago I delivered a beautiful baby boy, but I also gained almost 60lbs with my lil man so at my 6wk check up I asked my family doctor about starting Phentermine to help get back down to my pregnancy weight. She wouldn\’t let me start it until I my OB took me off my blood pressure/tachycardia medication that I was on due to severe Preaclamsia during my pregnancy. Well yesterday I finally was cleared and taken of the preaclamsia medication so my family doctor gave me the go ahead and I took my first pill. About 2 hours after taking my first dose I started having multiple heart palpitations. It was worse when I\’d go from a sitting to standing position, but also had them when I was sitting/laying…they were pretty consistent for about 2 hours. I didn\’t have any other symptoms with the palputaions. No dizziness, light headed or anything along those lines. I ended up taking one of my blood pressure medication and about a hour after taking it the palputaions stopped. I called my doctor and she told me to stop taking them and I have a appointment to see her Monday. I would really like to keep taking it. Has anyone ever had this problem and if so is it possible that my body just has to get used to the medication?

  27. I’ve been taking Phentermine for about two weeks. I’ve only been taking a whole pill for a week. My heart seems to flutter a lot and yesterday just on an easy walk my heart rate was about 160. Is that something I should be conserned about? I don’t get bad chest pains but sometimes I do get dull pains in my chest and I get so tired around mid-day that I take a nap(I do work). My husband is taking them and doing great with no issues. I don’t want to give up but I don’t want to jeopardize my health. I feel like a baby because they scare me so much and so many other people take them with no side effects. Any suggestions?

    • Hi Felicia, thanks for your comment! We’d recommend that you check with your doctor about the elevated heart rate, chest pains and fatigue. Phentermine affects everyone differently so even if your husband is doing great, your doctor may need to adjust your dose (or something else about your treatment plan). Either way, he or she would be the best person to assess whether or not these reactions are significant. Best wishes!

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