5-htp phentermine

5-HTP And Phentermine: Everything You Need To Know

General Phentermine Questions?
Check out the ultimate guide to phentermine weight loss pills!

While phentermine has undoubtedly helped many people lose weight since it first received FDA approval back in 1959, its period of effectiveness is limited to short-term use only, and it can often be less effective for some people than others. For this reason, researchers into phentermine are continuously trying to improve it by investigating how to maximize and prolong its period of effectiveness. Following this research, it is now quite typical to be prescribed a phentermine combination or to be prescribed supplements alongside phentermine. One of the most common and often talked-about supplements is 5-HTP, but what is it, and how does it help phentermine to be more effective? Read on to find out more about 5-HTP and phentermine!

What Is 5-HTP?

You’ve probably heard of serotonin, a crucial neurotransmitter which helps to control sleep, mood, and hunger, but in order to produce serotonin, 5-hydroxytrytophan (5-HTP) is necessary. Sufficient protein in the diet is typically all it takes to ensure adequate levels of 5-HTP, however our modern lifestyles can result in low levels of serotonin as a result of stress, poor diet, or lack of exercise. If levels have been identified as insufficient,  5-HTP supplements are available; 5-HTP supplements are made from either the seeds of the African tree called Griffonia, or synthetically produced in chemical laboratories.

5-HTP And Weight Loss

It is not so much the direct effect of 5-HTP as it is the effect of serotonin and the intricate mechanisms of sleep, mood, and hunger that are controlled by the interactions that take place within the process that affect weight. A lack of either compound causes symptoms which can then lead to weight gain, such as depression, insomnia, food cravings and additions. However, 5-HTP is more effective than serotonin as a supplement and appetite-suppressant, as 5-HTP can access the brain from the bloodstream, while serotonin supplements cannot.

The principle of 5-HTP and weight loss is most likely due to the interaction of functions taking place; 5-HTP causes improvements in important bodily functions and mood, which then has a positive knock-on effect on weight. For example, insomnia and obesity have been extensively studied with the resulting conclusion that there is an undeniable association between the two. Hence, if 5-HTP helps individuals alleviate insomnia, then additional weight loss is anticipated. Anecdotal evidence shows patients reporting significant improvements in their sleeping patterns, reduced insomnia and regulated sleeping times as a result of taking 5-HTP, which is also supported by feedback on the phentermine forum here.  Similarly, since depression is one of the main purposes for its use, emotional eating due to depressed moods is also likely to subside, which is also reported by users on the phentermine forum, as shown in this discussion thread here.

Most importantly, clinical trials have supported the positive outcome of weight loss and appetite suppression when 5-HTP supplementation was administered. One study concluded that 5-HTP reduced the intake of daily calories without the conscience effort to lose weight by any of the female participants, with weight loss in this particular study averaging as 3lbs over the course of five weeks. A second study involved a six week period without dietary restriction and the second six weeks with the addition of a 1,200 calorie diet. There was a marked increase in weight loss of participants taking the supplement versus those given a placebo. The average weight loss was 10.34lbs for the former group and 2.28lbs for the latter group. The conclusion of this study was that 5-HTP’s action on the satiety center of the brain caused users to take in fewer calories at meals, and ultimately, weight loss occurred!

5-htp phentermine

5-HTP And Phentermine

A medical study from 2009 on the treatment of obesity with combination pharmacotherapy stated that “Combining 5-HTP and phentermine generally results in greater weight loss than would be observed with either medication alone.” The author attributes this to the combination of chemical and naturally-occurring appetite suppressing properties, whereby 5-HTP, well-known for its use in serotonin deficiency syndrome, is recognized as a natural carbohydrate appetite satisfier which supports the appetite-suppressing effects of phentermine and strengthens their effectiveness across bodily functions. The study also states that, “Importantly, fewer stimulant side effects occur in patients treated with phentermine and 5-HTP.” This is something that the author expected to find, since 5-HTP administered at the same time as a stimulant decreases the side effects of the stimulant, and which has been consistently found in studies involving rats and humans. This therefore indicates that taking phentermine and 5-HTP at the same time can lessen the stimulant side effects that can occur with phentermine, such as anxiety and insomnia.

Furthermore, anecdotal evidence has found that patients who begin to experience reduced phentermine effects have reported that adding 5-HTP to phentermine results in improved appetite suppression and energy boosting effects. Many of these patients indicated that they felt the phentermine effects had been restored to their original strength, as experienced at the beginning of their phentermine prescription. This is particularly important with respect to establishing a way to prolong the effectiveness of the medication, as currently, phentermine begins to lose effectiveness within months, and many find that a second period taking phentermine is not as effective as the first. It is thought that phentermine starts to become less effective as it causes a depletion of neurotransmitters in the brain, as phentermine works by moving neurotransmitters from one place to another, but does nothing to increase the supply of neurotransmitters in the nervous system. Because of this, your brain slows down the production of neurotransmitters, but fortunately, no studies indicate that this effect is permanent.

One such way to overcome this problem is thought to be by using 5-HTP, which, as a naturally-occurring hormone pre-cursor, imitates the body’s own system of regulating appetite, sleep patterns and other important functions, therefore making up for the negative effects phentermine has on the body. Neurotransmitter functioning can also be improved with sufficient levels of amino acids, therefore it has also been proposed that multivitamins which supply sufficient levels of several important B-vitamins can reverse the depletion of neurotransmitters as a result of taking phentermine. This is because B vitamins are co-factors for the production of neurotransmitters from amino acids.

For these reasons, we recommend the new multivitamin supplement, Phen Vites, which has been developed especially for those taking phentermine. Phen Vites contain 5-HTP, therefore giving you the benefits of better results from your phentermine, an extended period of effectiveness, and reduced side effects as well as a range of B-vitamins, including B12, B6, folate (B9), and pantothenic acid (B5). In addition, Phen Vites contain many other essential vitamins and minerals that are typically lacking in our modern diets and which are essential for healthy weight loss. Through this combination of weight-loss inducing ingredients, Phen Vites are the only multivitamin you’ll need alongside your phentermine if you’re serious about making sure you reach your full potential while you’re on your weight loss journey with phentermine.

Have you taken 5-HTP and phentermine? If so, please let us know your opinions and experiences by commenting below!


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26 Responses

  1. So I was actually taking 5htp at the time my doctor prescribed phentermine. I never new anything about the 5htp boosting phen. About a month ago I ran out of 5htp and just haven’t picked anymore up. Today I decided to google why is my phentermine not working and came across this website and it make sense. I think I will start taking the 5htp again and see what happens.

    • Hi Lilly,
      Thanks for your feedback. We’ve seen a lot of people report added success with 5-HTP and phentermine. Good luck!
      Sally, phentermine.com

      • Hi, what is the dosage of 5 htp that you’re taking?

    • Where can we get the -htp phen vit?

  2. Is 5htp n phen vit the same??? If not what one is the best with phentermine?? I just started phentermine and 5htp 2days ago how should I take them?? How much 5htp and take together?

    • Hi Stephanie,
      Phen Vites are multivitamins which contain nutrients and vitamins that most multivitamins do not usually contain, such as 5-HTP, chromium and B12, as well as more typical vitamins such as vitamin A, C, E and folate. While 5-HTP is a good supplement to take alongside phentermine, Phen Vites combine a great variety of vitamins and minerals which all combine to help improve your body and its effectiveness at losing weight. For this reason, we recommend taking Phen Vites rather than 5-HTP alone or any other multivitamins.

      We would advise you to take both the 5-HTP and phentermine in the morning, and to follow the dosage instructions you have been given for both to know how much to take.

      Sally, phentermine.com

  3. I’m hesitant about starting phentermine due to the side effects I already have. After reading about Phen Vites, maybe just taking this multivitamin would give me the boost I need. Thoughts?? Thanks.

    • Hi Lorrie,
      While Phen Vites could help to boost weight loss, you would probably not get the amount of appetite suppression and added energy that might be necessary to help you lose a lot of weight. Phen Vites would be a good option to lose a small amount of weight or to maintain after you’ve lost weight, but we would recommend the phentermine alternative Phen Caps as the best product to really boost weight loss if you’re reluctant to take phentermine. Phen Caps have no side effects and have a lot of good feedback from customers, as you can see on the phen.com website here: https://www.phen.com/testimonials
      Sally, phentermine.com

  4. I’ve taken phen. Before I was off for about a year, this time around its not working. I’ve lost no weight, been tired. Would the 5-htp be good to help with me and if so how do I order these?

    • Hi Jennifer,
      You can buy 5-HTP as a supplement on its own, but we recommend the multivitamins Phen Vites, which contain 5-HTP, as well as vitamin B12, chromium, biotin and many other vitamins which can really help boost the effectiveness of phentermine. Here is a link to buy Phen Vites: https://www.phen.com/phenvites
      Hope that helps!
      Sally, phentermine.com

  5. Do you have the phen vitamins without fish? I have an ansikasis allergy, but would like to be able to benefit from them.

    • Hi Kat,
      It’s best to direct questions about Phen Supplements to their customer service department by emailing them at support@phen.com – they should be able to provide more info for you and answer your questions.
      Sally, phentermine.com

  6. I started phentermine in October, but went off for a month and am back on again. It gives me terrible mood swings. I get very irritatable, and cry often and become a little irrational. I’ve heard 5-HTP could help, does anyone have any experience with this? My Dr recommended St. John’s Wort, but I hear it’s not good to take with Phentermine and 5-HTP works better

  7. My doctor put me on celexa for anxiety and a week later put me on Phentermine, I\’ve seen mixed responses on if these should be taken together. Some say it boosted the effects and others say it can be dangerous and cause serotonin syndrome. Do you know where I could find the correct information about this?

    • Hello Randi. Thank you for reaching out.

      Sorry, we can’t offer you medical advice. As with combining any drugs, taking medications with phentermine is something that should only be done if it has been approved by a doctor. And, even if you have been told that it is fine to take a medication with phentermine, you should still remember to be extra vigilant about the possibility of additional side effects that may occur as a result of an interaction between the two medications, whether they have been prescribed for you or are non-prescription medications.

      You are welcome to join our brand new support group so you can connect with other phentermine users, share your experience and get some valuable advice. https://www.facebook.com/groups/1069871763087734/

      Rebeca, Phentermine.com

  8. Where can i buy just the 5htp

    • Hi Melissa,
      5-HTP is widely available in supplement and vitamins stores, supermarkets etc.
      Sally, phentermine.com

  9. Why does this webpage take you to phen caps? This does not appear to be the same as is in the description of phen vites, or the ingredients are different.

    • Hi Sheila,
      Unfortunately the Phen Vites are no longer in production so the links for this product take you to the general page for the site that used to sell Phen Vites. Phen Caps are an appetite suppressant and weight loss supplement similar to phentermine but non-prescription. By comparison, Phen Vites were a multivitamin supplement. As it is not possible to get Phen Vites any more, we would recommend that you ask at a vitamin store for something similar to help boost your weight loss potential.
      Sally, phentermine.com

  10. Hi, I take phenteramine 30mg. I would like to start with 5HTP – how many mgs is recommended??? thanks

    • Hi Johanna,
      As 5-HTP is not a regulated supplement, there is no overall recommended daily dosage. Anecdotal advice suggests that a supplement giving you between 150mg and 300mg per day is around the correct amount for most people.
      Sally, phentermine.com

  11. I\’ve been taking phentermine 37.5mg on the mornings and I\’ve been having trouble sleeping. I read where the 5-htp is a good supplement and may help balance the phentermine and maybe I can sleep. I wanted to know if I should take them at the same time daily ? I take the phentermine 1st thing in the morning

    • Hi Tanisha!

      We don’t know of any interactions; just make sure to double check with your pharmacist on possible contraindications.



  12. I have been taking phentermine 37.5mg in the mornings for about 8 months and I read where the 5-htp is a good supplement and may help the phentermine work like it did when I first took it. I wanted to know if I should take them at the same time daily? And would it help me if I took a second dose of 5-htp 200mg around 4pm to help with my late night cravings?

  13. Can I take phen and 5htp at the same time in the morning?

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