anyone tried ACCOMPLIA

[doz12345]

Hello all
today i have started to take Accomplia,i know this quite new out and was wondring if anyone has taken this and how they got on.I have spoken to one girl who felt very sick on them and moody.
I would be grateful for any feedback on this

Dorothy

[UK-GIRL]

Hey hun

How you getting on with it??

Sammie x

[TickleMySwollenTuna]

Where did you get accomplia?

[skychick]

It's been awhile since I posted on Phentermine.
But doing a google search, I found this thread on Accomplia.

I just got a prescription for it today. Can you tell me how you are doing on it so far?

Thank you!

skychick

[pamelaqui]

Seriously. How did you get a perscription for Accomplia... is it in the states???

I want Accomplia...!

[papasmurf]

Someone who has taken accomplia, can you tell me what the pills taste like? How long was it before they reduced hunger? I want to figure out if I have the genuine article or phony stuff.

Pamela, it's not yet approved in the US. The FDA has ruling put off until the end of 2006 or early 2007.

[SuddenlyISee]

I took Acomplia. I had a horrible reaction to it. It felt like I had the flu.... nausea, high fever, chills, muscle aches and pains in my lower abdomen. I was so excited about starting it too, not to mention it was expensive.

[SgtRocksBaby]

I've been looking into accomplia recently as well as the phentermine that I am currently taking and am wondering if anyone can update this thread with any information about it. Thanks.

[SgtRocksBaby]

Eek after just reading an article out on 20 Jun 07 that states it increases suicidal thoughts and discussing other terrible things about it, not to mention the cost...sheesh...I don't believe I'm interested in this as an alternative to phentermine anymore...lol

[tekmiester]

The stuff really works. You can buy it here: Acomplia

[spydergirl]

at ****************
i got it there they provide tracking, great service and basically its really cheap and confidential. i lost about 10 lbs but i stopped taking it after a month because i was on vacation in holland.

**edited by mod**

[bigred55]

I started Acomplia today. Got it from an Indian pharmacy with a Canadian name, hope it's the real stuff. I'd be interested in knowing how one figures that out. I know you can put Adipex to your tongue & taste the bitterness to test for genuine product, but I'm not sure how to make sure the Acomplia I received are not just sugar pills.

I started today as I said & felt no difference at all. Does anyone know if it takes time to build in your system or if it's supposed to work immediately?

I'd be really interested in hearing from any of you. I'll keep you posted.

[allycouture]

I found these articles on Acomplia

Acomplia Side Effects: The Story You Must Read

UPDATE: May 2007. The drug has been re-named Zimulti in the US.

UPDATE Jun 13 2007: An FDA advisory panel of outside experts unanimously recommended that the regulatory agency not approve the novel weight-loss drug for sale in the United States. It is unlikely that this drug will be approved before 2010 (if at all).

UPDATE July 1 2007: Sanofi has now withdrawn it's application for approval in the USA.

Background
Rimonabant (brand name Acomplia) has been pitched as the blockbuster weight loss drug of the decade. The company manufacturing the drug, Sanofi-Aventis believes that sales will reach $5.2 billion per year by 2010. That is a staggering amount of money.

Investors are getting swept up in the buzz, and desperate consumers are falling over themselves to get an opportunity to try the drug. However it is currently before the FDA awaiting approval - which some believe may come during early/mid 2006. Acomplia blocks cannabinoid (CB) receptors in the brain. The CB receptors are believed to play a role in controlling food consumption and dependence / habituation. People often refer to the cannabis-induced "munchies" or hunger pangs. Acomplia attempts to do the opposite.
What is an Acceptable Risk?
In the scramble for profits and quick-fix obesity solutions - no one has bothered to raise questions about the long term side effects. It is up to the health authorities to determine what is an "acceptable risk" based on the data from the clinical trials conducted recently.

Carol (not her real name) knows about the risk - and it is anything but acceptable. I recently corresponded with Carol, who participated in a Rimonabant drug trial.

With a long history of dieting, Carol began the trial at a weight of 13 stone 1 pound (183 pounds). With a daily dosage of 20mg, Carol noticed two immediate reactions; She was less hungry, and she became very tearful and depressed. She began to lose a pound or two per week (without being on a diet or exercise program).
Psychosis?
However things went from bad to worse. "I also felt nauseous quite often and in a period of 3 months vomited 6 times. As the trial progressed I became more and more depressed. I felt suicidal most of the time." In her desperation to lose weight, Carol stayed on the drug, but slowly descended into psychosis "I couldn’t sleep and when I did I had terrible nightmares". Carol experienced more graphic symptoms of psychosis (such as self-inflicted violence). She has since been on anti-psychotic medication for over a year, and has gradually improved.

"I lost my health and happiness because of these pills and experienced the most wretched time of my life". Carol also added "My relationship with my partner never recovered from him having to care for me and we split up at the end of last year."

To add insult to injury, the 20 pounds that Carol lost in the trial came back on within 3 months. Carol reports that her appetite "came back with a vengeance".

Not Alone
According to the results of the 1st year of clinical trials, patients taking the 20mg dosage of Rimonabant reported 50% more adverse events leading to discontinuation, than those in the placebo group. Of course Carol's experiences must be kept in perspective - most people had no adverse side affects.


» Note the increase in psychiatric disorders as dosage increases

What is an Acceptable Risk?
Is even one persons terrible experiences an "acceptable risk"? Maybe Acomplia will end up being prescribed to only the most "at-risk" obese patients - but who decides where that line lies?
Cover Up?
You will not read about Carol's experiences in any published paper. The data from the 2004 trial that Carol participated in has not (yet?) been made public. Sanofi funded the trial and holds the results.
There Will Never Be a Perfect Weight Loss Drug
In amongst the flurry of hype and expectation over this new "wonder drug", someone needs to take a long hard look at the whole concept of miracle weight loss cures. For the sake of 20 pounds of weight, Carol damaged her mental health, and her relationships.

Carol strongly cautions anyone with any history of depression to be "very careful" about taking Acomplia/Rimonabant - "Being thinner is not worth screwing up your mental health."

$5.2 billion dollars estimated per year. With that sort of money being generated, who will care if a few people lose their minds?

Sanofi-Aventis "Because Health Matters"
2005 Worldwide Pharma Sales: 27,311 Million Euros (33 Billion USD).
100,000 employees worldwide (including a sales force of 33,000).
Present in more than 100 countries.
It is possible that Acomplia may be marketed as a Cardiovascular medication. US health insurers generally cover cardiovascular medication.


Article #2

Acomplia / Zimulti (Rimonabant) Side Effects


While Acomplia has been approved for sale in Europe, uncertainties remain about rimonabant's side effects.

Researcher Luc Van Gaal of the University Hospital in Antwerp, Belgium, said 14.5 percent of patients participating in one of the large clinical trials who were on the 20 mg dose stopped taking Acomplia due to adverse side effects. The main side effect, he said, was nausea, which affected one in eight patients.

An earlier clinical trial also had a drop-out rate due to side effects of about 15 percent.

Probably the most objective and comprehensive evaluation of side effects available at the moment is the one published as part of the approval process by European Medicines Agency (EMEA).

This was its report.

ACOMPLIA 20 mg has been evaluated for safety in approximately 2,500 patients enrolled in studies that examined the metabolic and weight loss effects in overweight and obese patients and in approximately 3,800 patients in other indications.

In placebo-controlled studies, the discontinuation rate due to adverse reactions was 15.7 % for patients receiving rimonabant. The most common adverse reactions resulting in discontinuation were: nausea, mood alteration with depressive symptoms, depressive disorders, anxiety and dizziness.

Depressive disorders were reported in 3.2% of obese patients, or overweight patients with associated risk factor(s) treated with rimonabant 20 mg. These were usually mild or moderate in severity and resulted in recovery in all cases either after corrective treatment or discontinuation of rimonabant and did not exhibit any differentiating characteristics compared to cases reported in the control groups.

The following table shows all treatment-emergent adverse reactions from four placebo-controlled studies in patients treated for weight loss and related metabolic disorders when these incidences were statistically significantly greater than the corresponding placebo rate (for events greater than or equal to 1 %) or considered clinically relevant (for events fewer than 1 %).

Classification of expected frequencies of undesirable effects:

Very common (More than 10 out of 100); Common (More than 1 in 100 but fewer than 10 in 100); Uncommon (More than 1 in 1,000 but fewer than 1 in 100); Rare (More than 1 in 10,000 but fewer than 1 in 1,000); Very rare (Fewer than 1 in 10,000), Not known (cannot be established from the available data).

Within each frequency grouping, undesirable effects are presented in order of decreasing seriousness.

[cindy83]

I wanted to try Acomplia too but when I hurd about its side effects I said no thank you. Just when I was about to order I found a very interesting article that made me change my mind. I hope this will help http://www.bestdietpillsresource.com...ion-and-review
Hope you guyz change your mind about it too.

[davidoff]

I was a skeptic person in terms of weight loss pills until I used Acomplia. It helped me to lose 18 kg in 8 months and now I want to take a pause of one month now and intend to restart it after Christmas as I've to lose about 10 more kg, hope not to add much over the Christmas period
The only side effects I had were some sleeping troubles that are away now.
I used to buy my pills from www.e-medsfree.com and I do save a lot.

[rosa899]

I was a skeptic person in terms of weight loss pills until I used Acomplia. It helped me to lose 18 kg in 8 months and now I want to take a pause of one month now and intend to restart it after Christmas as I've to lose about 10 more kg, hope not to add much over the Christmas period
The only side effects I had were some sleeping troubles that are away now.
I used to buy my pills from www.e-medsfree.com and I do save a lot.

I checked this website and it seems to be safe. But I tried to go through my order with no success... wat can be the problem? any ideas...

[davidoff]

It depends what card you've used. As I know they accept Visa, Master, Maestro... anyway I paid by bank transfer
you have to contact the site and seek their bank details or help to place the order by credit card
good luck!

[Valerie61]

There is no way to determine if a pill is the real drug by tasting. There are many ingredients that can be used in fake pills to imbue them with a bitter "pill-like" taste. For US citizens, buying drugs from foreign pharmacies can be risky. Because there is no FDA assurance that you will receive the real drug, or for that matter, any drug at all, but a placebo. Orders from foreign pharmacies, even Canadian pharmacies can be seized by customs. Numerous people here have posted that their orders were seized, or that they got a product that had no effect whatsoever. Accomplia is not a legally prescribed drug in the US.

[davidoff]

Right, many foreign pharmacies are risky as well as their products but www.e-medsfree.com is a reliable site and they sell genuine pills. I do trust them as I use their products for 8 months and Acomplia pills they sell work good for me.
All orders that I received from this site arrived from an European country in a discreet envelope so I've never had any Customs problems.

[rosa899]

hi again davidoff, my order is pending for 2 days; do you know what may be the problem? I'm a little worried now as I've never bought before on this site ...

[davidoff]

maybe they have a delay due to the holidays... you'd better contact them and ask if everything's ok

[rosa899]

Hello
here I am again. I've got my Acomplia order just before Christmas, it was a little longer than I expected however the order arrived safe. I'm taking the pills for 3 weeks now and I do combine them with healthy eating and exercises. I've lost 1.5 kg, hope to lose more on next months lol