I've done a lot of reading about fen-phen and fenfluramine on its own.
fenfluramine, especially when combined with phentermine, was the cause of 2 major problems: heart valve damage, and primary pulmonary hypertension.
Sometimes heart valve damage isn't detected until you are actually tested. The best test is the echocardiogram, it's non-invasive, easy to adminster, and easy to read. All people who have taken fen-phen are advised to have echocardiograms. Damage can show up YEARS after you stopped taking fen-phen.
In 1999, in the largest study of its kind, researchers found people taking fen phen for longer than six months experienced heart valve disease at an unusually high rate. The findings were presented at the annual meeting of the American College of Cardiology. According to the study, people who never took fen phen had a 3.6 percent incident rate of heart valve disease. Of 1,163 former fen phen users included in the study, people who had taken the drugs for less than six months had a 4.5 percent incident rate, which increased to a 7.0 percent incident rate of heart disease among people who took the drug for six months to a year.
Once users had exceeded one year on fen phen up to two years, the rate increased to nearly double the incident rate of the heart disease to 13.6 percent. At more than two years, the rate was a high 17.4 percent.
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