didrex

[crunch]

anyone with thoughts on this diet pill?? i here its way stronger than phentermine

[I Gained the Freshman 25]

Which Pill Is Most Effective?
Conclusion

Based on our findings below, allowing for the fact no one person reacts to treatment exactly like another, and based on an agreement that weight loss needs to be an ongoing program. It would appear that the relative order of efficacy Vs longevity Vs side effects amongst the noted medications is;

1st - Meridia
Joint 2nd - Phentermine
Joint 2nd - Xenical
4th - Tenuate
With Bontril & Didrex relatively unknown quantities with major reservations.

We would point out;
1) We are able to sell any and all of the above medications.
2) We have no connection or commercial bias to any one or more of the above.
3) For certain patients, e.g. the seriously obese, drug combinations (e.g. Phentermine & Xenical) may be advisable and therefore render the above inappropriate. Although, from our research, many drug combinations appear to offer little or no benefit over single drug usage for weight loss. Phentermine with, and then followed by Xenical. Might well compete for 1st place with Meridia, due to the potential weight maintenance properties of Xenical.
4) There was no one single source for the information we collated, and the clinical trials were conducted by different organizations at different times (e.g. the only duration Phentermine clinical trial was conducted many decades ago!)

For even more profound findings / reports, please read our findings below! (But please, please, please, put these findings in context of the drug disclosure pages and your own personal status).

Meridia
This is a relatively new medication, and was treated with some concern when it was first released / approved, as it is "Serotoninergic" agent. This is the same general classification as "Fen" (Fenfluramine & Dexfenluramine); 2 drugs withdrawn from the market after they were associated with heart disease. However, unlike "Fen", Meridia (Sibutramine) does not get inside the hypothalamus cells to boost the release of certain agents (as Fen does), but rather works outside these cells and simply stops these agents being reabsorbed.

Meridia has proved relatively side-effect free, and even has beneficial effects on glycemic control and cholesterol. Unlike some other weight loss drugs, it is almost universally accepted suitable for long term administration / treatment. As weight loss / maintenance majoratively needs to be an ongoing process, this puts it ahead of medications that are suitable only for initial weight loss.

In clinical trials, only 7% of participants failed to complete the course through adverse affects. The average weight loss was around 5 Kg on 20mg strength over 8 weeks, with maximum weight loss achieved around 3 to 5 months (11 Kg / 24 lbs). Which made Meridia as effective as the so-called "anorexiants". Weight maintenance was thereafter significantly higher with continued usage then without.

One other benefit of Meridia seems to be that it was originally investigated as an antidepressant (but proved more effective as an obesity medication!). However, many users have commented on a slight, but noticeable feeling of well being whilst taking this drug. As obesity is also linked with depression, this certainly seems to be proving a useful secondary facet.

Having said this. In a recent non-clinical trial conducted by an obesity news site, 27% of people gave up on Meridia due to lack of efficacy! And reported that many others had significantly less weight loss then in other, clinical trials. One of the reasons concluded by them was that many / most of the respondents had previously taken anorexiants, such as Phentermine. In which case, this may well have limited the ability of Meridia and may make it suitable only for patients who have not previously taken other obesity medications.

However, as respondents in the above trial probably had unrealistic expectations of Meridia (having lost weight with Phentermine, there was not much extra scope to lose weight with Meridia), and this was not allowed for in the trial. It would appear the original clinical trial to be more realistic for new diet pill patients. In consequence, it would seem that their survey should have been in two parts. The first for new patients, the second for ex-Phentermine patients to see which is most effective (Phentermine, Meridia, or Xenical) to maintain weight loss. We believe, therefore, this trial was partly ill conceived.

Please also refer to our Meridia Disclosures / Information Page.

Phentermine (AKA Adipex & Ionamin)
Phentermine is an "Anorexiant" medication, which are attributed with offering the fastest / greatest initial weight loss (In conjunction with a strict diet and exercise, an average respondent loss of around 12 kg / 26 lbs in only 24 to 36 weeks has been studied). Also, in the trials, only 5.5% of people failed to complete the course through adverse reactions.

Phentermine has had a bad associative name with Fenfluramine & Dexfenluramine (commonly known as "Fen", thus "Phen/Fen" when they were used with Phentermine). They were combined as they act differently on the body, and produced much greater results. However, due to the way Fen works, it was deemed to cause serious heart disease in some patients, and was withdrawn from the market. Of course, this left a bad taste with Phentermine. But the FDA have actually stated on their information page, that no cases of heart disease have been subsequently associated with Phentermine alone. In other words, it was solely Fen that caused these problems.

Most authoritative sources believe that Phentermine is only suitable for initial weight loss / treatment, not ongoing weight maintenance / prescription. A number of sources have shown that significant numbers of users find that Phentermine ceases to become effective after 12 weeks of use (Including the FDA which approved the drug for short term use). In fact, the European Union has banned Phentermine, not based on new health issues, but because it questions the ongoing effectiveness / suitability of Phentermine.

Having said that. A number of recognized authorities, including one US National Institute, showed anorexiants being used effectively over 4 years. Also, one very useful finding in another study, concluded that using anorexiants for 4 weeks on, 4 weeks off. Was virtually as effective as using them continuously. That's right! It may be just as well to order a supply of Phentermine, but use them over twice as many months.

In fact, recommended prescription dosage levels start at 15mg for Phentermine. So, it is quite feasible to buy 30mg / 37.5mg tablet form medication, and literally split them in two (using one half per day) as many Viagra users are prone to doing!

Also, the main supplier(s) we use when you order from this site, offer 60 and 180 by 15mg capsules of Phentermine, supposedly / respectively for 30 and 90 day usage (2 a day). But as the prescribing information for Phentermine recommends you take your course in the morning, there really is no point to buying your 30mg dosage in two 15mg capsules. Unless, of course, you decide to only take 15mg per day!

As a foot note. Adipex-p is simply a branded, tablet form Phentermine. Ionamin is a branded type of Phentermine where the drug is set in resin, so as to produce a time release medication / pill. Some people, with sensitive stomachs or other reactions to immediate release generic Phentermine / Adipex-p, prefer Ionamin. Other people say that they have found time release reduces effectiveness.

Please also refer to our Phentermine Disclosures / Information Page.

Xenical
Xenical (Orlistat) is unique amongst the diet pills, because it works as a stomach lipase inhibitor (a fat blocker). It prevents these cells from absorbing / converting 30% of dietary fat. Because it does work completely differently to the other drugs, there are arguments for its combined use with either Phentermine or Meridia for the seriously obese. However, much of what we researched failed to show any significant benefit with such combined use.

Xenical is recognized as a long term use medication by virtually every authority. Which puts it ahead of Phentermine in this respect. But it appears to be less effective in regard to maximum possible weight loss. In a clinical trial with combined special diet and exercise program, the average weight loss was 5.45 Kg / 12 lbs. However, because Phentermine and Xenical have been used safely together in trials. There may be a case for using Phentermine to lose weight, and thereafter Xenical to maintain weight.

Side effects with Xenical have been shown to be minimal. With undigested fat excretions (which is actually and physcologicallyl a good sign) being the main "problem". Also, multivitamin supplement use is recommend when taking Xenical, as it does affect absorption of these too.

Please also refer to our Xenical Disclosures / Information Page.

Tenuate
Tenuate (Diethylpropion) is an "Anorexiant" like Phentermine. But we have found absolutely no clinical trial information to base any report on (other than it is an anorexiant, and that many sources generically state anorexiants as offering fast initial weight loss). It is also one of the drugs banned by the European Union alongside, and for the same reasons as Phentermine. It is only placed as 4th in our conclusion, by fact that we have uncovered negative statements concerning Didrex and Bontril-SR.

Please also refer to our Tenuate Disclosures / Information Page.

Didrex
Didrex (Benzphetamine) is a FDA rated class 3 drug. The lower the number, the higher the abuse risk factor (that is is why heroin is class 1, and amphetamines class 2). All the other drugs listed here (except Fen, which has been withdrawn, and Xenical, which has a lower risk "**" classification), are class 4. This means Didrex supposedly has a higher risk factor. It has also been associated with causing birth defects.

We could find no clinical study / trial information on this drug.

Please also refer to our Didrex Disclosures / Information Page.

Bontril-Sr
Bontril-SR (Phendimetrazine) is another stimulant prescribed for weight loss. Some physicians are reported to prescribe it in combination with Phentermine to reduce drug tolerance. But we could find no clinical study / trial information on this drug.

However, we have rated it as least suitable / effective along with Didrex, simply based on the fact, the original manufacturer, Wyeth-Ayerst Laboratories, issued possible warnings of "possible valvular irregularities and primary pulmonary hypertension" regarding their product, and now no longer appear to be associated with it.

In addition, we have seen warnings that Phendimetrazine is habit forming. The only other information we found, is that the US Division of Drug Marketing, Advertising, and Communications issued a warning to the present manufacturer, Carnrick Laboratories, about information they produced. The warning stated "the brochure is lacking in fair balance because there is no risk information in the presentation".

[continuingtofade]

they say meridia is effective when it comes to stabilizing brain chemistry, but phen is a lot more potent of an appetite suppressant. meridia also has to be taken completely alone... i heard that its interaction with certain herbal supplements may cause stroke or death. besides, it's so damn expensive..

[verticalchallenge]

I tried DIDREX and it did NOTHING!! It was a complete waste of money! The only way I could even get a mild appetite supression was by taking two!! And the effect was so minor I was sure I got ****** off and was taking a sugar pill. But some they say didrex is the strongest diet drug, they are wrong!! (At the time I was working out religiously 3x a week)I actually got interested in didrex from a body building web-site. The advice was to take them for two weeks before competetions... but I'm not a body builder so... everyone is different, but don't believe the hype!! I take 1/2 a 37 phen a day and this is like 4 or 5 didrex!!!! find what works!

[thanatos]

i've heard didrex is the next best thing to speed. guess i should look into it again?

[ski_chick]

I ordered Didrex the day before I discovered this forum. I was considering Phentermine, but had no idea what the difference was between the pills and capsuls and how many mg to get. So I got Didrex instead.

It's been exactly one week yesterday and I lost 4.5 lbs. So I guess it's working. I sleep perfectly fine at night. During the day I have enegry, but I don't feel like I'm on speed and I'm not jittery at all. I don't sweat like a lot of people say they do on this forum w/ Phen. I drink lots of water, have dry mouth once in a while, but nothing major. Basically, I seem to have ZERO side effects - which for me is great b/c I'm the type of person that if there's a possible side effect - I DO get it.

With Phen, I hear that people's appetites are suppressed so much that they have to FORCE themselves to eat otherwise they could go without eating all day. I don't think Didrex is quite like that. I still feel hunger once in a while, but if I eat a small light-n-lively yogurt that's more than enough for me. Of course, I've hardly been eating at all, which I'm trying to change now. One day last week lunch consisted of an apple and a slim fast and I was good to go! Not that that's a healty way of living. I know that to keep the weight off permanently, I need to learn to eat better as a whole and make it a lifestyle change, so I'm working on that part. But as for the weight loss for the time being, it seems to be working.

[Brianasmom]

I was on phen for 2 months then I felt like it was no longer working so I got an order of Didrex. I swear my Metabolite works better. There is some days where I can't remember if I took one or not. I think it did nothing for me. I couldn't even lose one pound.I wish I would have saved my money and used it on more phen. hope this helps.

[pdxguy]

Hey;

I ordered a script of Didrex when I noticed the Phen beginning to not take me through the whole day. I paid 218 for three months worth (#90 50mg pills) and found that they did absolutely nothing for me.

They did so much nothing to the point that I took the bottle to a local pharmacy to make sure I didn't get ****** off with some placebo or fake. They were the real deal. As a side note that I found interesting is that on the label the doctors instructions indicated I could take up to 3 a day if necessary. I am a big guy (6'4 and #274) so I'm not sure if that was the reason for the larger dose or if it is because they just dont work real well for most people as a whole.

Anyone know why it puts asterisks in my post? I assume that some script is seeing that word as vulgar or profane...but it's not.

Rob

[MargoV]

I tried Didrex. It did absolutely nothing for me.

MargoV

[Daphne_X]

Hi Crunch!
I have tried Bontril, Didrex and Phentermine and I personally prefer Phentermine 37.5 (blue and white tablets) the best. Good luck with whatever you choose.

[HollyAsWell]

Mmm, I've read there is a class action lawsuit pending against the makers of Meridia....http://www.meridia-side-effects-lawyers.com/....http://www.meridiaclasslaw.com/

Of course, this doesn't really mean anything because the FDA has not pulled the drug.

[HollyAsWell]

Also wanted to add that I have taken xenical and didn't even bother with it past 1 week. The way it works is that it grosses you out so much you stop eating altogether in fear that what you might ingest may have fat in it. You literally have to wear something close to an adult diaper with that stuff because you leak fat out of your behind region constantly. It's putrid and digusting and supposed to be a psychological attempt at getting you to cut down on your fat intake. I cut out my xenical intake instead.