[Butter Buns]

You can do a search on your own on the Discovery Health website for drug interactions, but here is the scoop about mixing Phen and Lexapro or any Seratonin reuptake Inhibitor (SRI):

GENERALLY AVOID: Several case reports suggest that patients treated with serotonin reuptake inhibitors may exhibit an increased sensitivity to sympathomimetic agents. The mechanism of interaction is unclear. The reasction has been reported when fluoxetine was used concomitantly with phen, amphetamine or phenylpropanolamine. Additionally, some sympathomimetic agents (e.g, amphetamines) may possess serotonergic activity and should generally not be administered with SRIs because of the additive risk of serotonin syndrome, which is a rare but serious and potentially fatal condition thought to result from hyperstimulation of brainstem 5-HT1A receptors. The interaction occurred in a patien treated with dexamphetamine approximately 2 weeks after the addition of venlafaxine. The medications were discontinued and the patient was given cyproheptadine for suspected serotonin syndrome, whereupon symptoms promptly resolved. A second episode occurred when dexamphetamine was subsequently resumed and citalopram added. The patient improved following cessation of citalopram on his own, and residual symptoms were successfully treated with cyproheptadine. MANAGEMENT: In general, amphetamines should not be combined with SRI's. Close monitoring for enhanced sumpathomimetic effects is recommended if these agents must be used together. Patients should also be monitored for signs and sumptoms of excessive serotonergic activity such as CNS irritability, altered consciousness, confusion, myoclonus, ataxia, abdominal cramping, hyperpyrexia, shivering, pupillary dilation, diaphoresis, hypertension and tachycardia.

Sorry for the bad news...I quit taking my lexapro. I'd rather be skinny and *****y than big, nice and dead!